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Ten IRBs gave the study expedited review because they judged it as minimal risk, 31 gave it full board review because they viewed it as more than minimal risk, one declared that the study was exempt from review, and one refused to approve the study on the grounds that it was too risky ( Green et al 2006). 3 For example, Green et al (2006) found significant variation in IRB risk/benefit evaluations of the same study reviewed at 43 different research sites. Lack of regulatory guidance concerning risks and benefits may lead to inconsistent IRB decisions in the same or similar cases.

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2 The Department of Health and Human Services (2009) regulations, otherwise known as the Common Rule, state that for an institutional review board (IRB) to approve research it must determine that “Risks to subjects are reasonable in relation to anticipated benefits, if any, to subjects, and the importance of the knowledge that may reasonably be expected to result (45 CFR 46.111a2).” Regulations in other countries and international ethical guidelines include similar statements ( Australian National Government 2015, Canada Institutes of Health Research 2005, Council for the International Organization of Medical Sciences 2002, United Kingdom Department of Health 2011, World Medical Association 2013).Īlthough the idea that risks should be acceptable in relation to expected benefits has widespread acceptance, there is little guidance on how to interpret or apply this principle because regulations and guidelines do not clearly define “risks” and “benefits” nor do they say what makes risks acceptable (or reasonable or justified) in relation to expected benefits ( Levine 1988, Kimmelman 2004, Rid et al 2010, Rid and Wendler 2011). One of the key principles 1 of ethical research involving human subjects is that risks should be acceptable in relation to expected benefits ( Emanuel et al 2000). The fact that IRB risk/benefit decision-making involves intuition need not imply that it is hopelessly subjective or biased, however, since there are strategies that IRBs can employ to improve their decisions, such as using empirical data to estimate the probability of potential harms and benefits, developing classification systems to guide the evaluation of harms and benefits, and engaging in moral reasoning concerning the acceptability of risks. In this paper, I examine the role of intuition in IRB risk/benefit decision-making and argue that there are practical and philosophical limits to our ability to reduce our reliance on intuition in this process. Some have objected to using intuition to make these decisions because intuition is unreliable and biased and lacks transparency. Institutional review board (IRB) members often rely on intuition to make risk/benefit decisions concerning proposed human studies. For more information, please review GoLookup Terms of Use.One of the key principles of ethical research involving human subjects is that the risks of research to should be acceptable in relation to expected benefits. GoLookUp does not make any representation or warranty about the accuracy of the information available through our website or about the character or integrity of the person about whom you inquire. (These terms have special meanings under the Fair Credit Reporting Act, et seq., ('FCRA'), which are incorporated herein by reference.) The information available on our website may not be 100% accurate, complete, or up to date, so do not use it as a substitute for your own due diligence, especially if you have concerns about a person's criminal history. GoLookUp does not provide consumer reports and is not a consumer reporting agency. Mugshots and/or arrest records published on this website are in no way an indication of guilt and do not represent any evidence an actual crime has been committed.ĭISCLAIMER: You may not use our service or the information it provides to make decisions about consumer credit, employment, insurance, tenant screening, or any other purpose that would require Fair Credit and Reporting Act (FCRA) compliance.

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